Proteins are the building blocks of life, and consequently, scientists have long studied how they can improve proteins and design completely new proteins that perform new functions and processes.
Traditionally, new proteins are created by either mimicking existing proteins or manually editing the amino acids that make up the proteins. This process, however, is time-consuming, and it is difficult to predict the impact of changing any one of the amino acid components of a given protein.
In this week’s APL Bioengineering, researchers in the United States and Taiwan explore how to create new proteins by using machine learning to translate protein structures into musical scores, presenting an unusual way to translate physics concepts across disparate domains.
Each of the 20 amino acids that make up proteins has a unique vibrational frequency. The chemical structure of entire proteins can consequently be mapped with audible representations, using known concepts from music theory like note volume, melody, chords and rhythm. The specific sounds generated, determined by the way a protein folds, can be used to train deep learning neural networks.
“These networks learn to understand the complex language folded proteins speak at multiple time scales,” said Markus J. Buehler, from the Massachusetts Institute of Technology. “And once the computer has been given a seed of a sequence, it can extrapolate and design entirely new proteins by improvising from this initial idea, while considering various levels of musical variations—controlled through a temperature parameter—during the generation.”
The team compared the new proteins against a large database with information about all known proteins and used molecular dynamics equilibration and characterization by using a normal mode analysis. Through these steps, the researchers demonstrated the method could design proteins that nature had not yet invented. The new proteins appear to be stable, folded designs, and scientists created an algorithm to materialize music from sound waves to matter.
“This paves the way for making entirely new biomaterials,” said Buehler. “Or perhaps you find an enzyme in nature and want to improve how it catalyzes or come up with new variations of proteins altogether.”
By adjusting the temperature, the number of variations the algorithm creates can be increased. The new mutations can be measured to see which are most effective as enzymes, for example.
The “protein music” (https://soundcloud.com/user-275864738) the researchers uncovered could also help create new compositional techniques in classical music by illuminating the rhythms and tones of proteins, a method Buehler refers to as materiomusic.
“In the evolution of proteins over thousands of years, nature also gives us new ideas for how sounds be combined and merged,” said Buehler.
Original post: https://phys.org/news/2020-03-proteins-artificial-intelligence.html
I am the manager of JustCBD label (justcbdstore.com) and I’m presently trying to develop my wholesale side of company. I really hope that someone at targetdomain give me some advice . I thought that the very best way to accomplish this would be to talk to vape shops and cbd retailers. I was really hoping if anyone could suggest a qualified web-site where I can purchase Vape Shop B2B Leads I am currently reviewing creativebeartech.com, theeliquidboutique.co.uk and wowitloveithaveit.com. Not sure which one would be the best selection and would appreciate any guidance on this. Or would it be easier for me to scrape my own leads? Ideas?
I’m the owner of JustCBD Store label (justcbdstore.com) and am aiming to broaden my wholesale side of business. I really hope that someone at targetdomain share some guidance ! I thought that the best way to accomplish this would be to connect to vape companies and cbd stores. I was really hoping if anybody at all could suggest a dependable web-site where I can purchase Vape Shop Sales Leads I am currently looking at creativebeartech.com, theeliquidboutique.co.uk and wowitloveithaveit.com. On the fence which one would be the most ideal choice and would appreciate any advice on this. Or would it be much simpler for me to scrape my own leads? Ideas?
I used to be able to find good advice from your articles.
It’s difficult to find well-informed people on this topic, but you sound like you know what you’re talking about! Thanks
You’re so awesome! I do not suppose I’ve truly read through anything like that before. So good to discover another person with a few original thoughts on this topic. Seriously.. thank you for starting this up. This site is something that is required on the internet, someone with some originality!
Good article. I will be dealing with a few of these issues as well..
Great blog you’ve got here.. It’s hard to find excellent writing like yours nowadays. I seriously appreciate individuals like you! Take care!!
Saved as a favorite, I really like your site!
Good post. I learn something new and challenging on sites I stumbleupon on a daily basis. It will always be helpful to read articles from other writers and use a little something from their sites.
This is a topic that is near to my heart… Many thanks! Where are your contact details though?
This website was… how do you say it? Relevant!! Finally I have found something which helped me. Kudos!
Oh my goodness! Impressive article dude! Thanks, However I am having issues with your RSS. I don’t understand the reason why I cannot join it. Is there anybody else having the same RSS problems? Anyone who knows the answer will you kindly respond? Thanks!!
I’m amazed, I must say. Rarely do I come across a blog that’s both equally educative and amusing, and without a doubt, you have hit the nail on the head. The problem is something which not enough folks are speaking intelligently about. I am very happy that I stumbled across this in my search for something regarding this.
I love reading a post that will make people think. Also, many thanks for allowing me to comment!
Hello, There’s no doubt that your web site might be having internet browser compatibility problems. When I look at your web site in Safari, it looks fine but when opening in IE, it has some overlapping issues. I just wanted to give you a quick heads up! Apart from that, fantastic blog!
Good day! I could have sworn I’ve visited this site before but after browsing through a few of the posts I realized it’s new to me. Anyhow, I’m definitely happy I discovered it and I’ll be bookmarking it and checking back regularly!
After looking into a few of the blog articles on your web page, I seriously like your way of writing a blog. I saved it to my bookmark website list and will be checking back soon. Please visit my web site too and let me know your opinion.
Oh my goodness! Impressive article dude! Thanks, However I am going through problems with your RSS. I don’t know why I am unable to subscribe to it. Is there anybody having similar RSS issues? Anybody who knows the solution can you kindly respond? Thanks!!
After I originally left a comment I seem to have clicked the -Notify me when new comments are added- checkbox and from now on each time a comment is added I get four emails with the same comment. There has to be a means you are able to remove me from that service? Cheers!
Hello, There’s no doubt that your website could be having web browser compatibility problems. When I look at your blog in Safari, it looks fine but when opening in IE, it has some overlapping issues. I just wanted to provide you with a quick heads up! Apart from that, excellent website!
Good article. I will be dealing with a few of these issues as well..
The very next time I read a blog, I hope that it doesn’t disappoint me as much as this particular one. I mean, I know it was my choice to read, nonetheless I genuinely believed you’d have something helpful to talk about. All I hear is a bunch of complaining about something you could possibly fix if you were not too busy searching for attention.
This is a topic that is near to my heart… Cheers! Where are your contact details though?
This page definitely has all of the information and facts I needed concerning this subject and didn’t know who to ask.
An impressive share! I’ve just forwarded this onto a colleague who had been conducting a little homework on this. And he actually ordered me lunch simply because I found it for him… lol. So let me reword this…. Thanks for the meal!! But yeah, thanx for spending time to talk about this subject here on your website.
I enjoy reading an article that will make men and women think. Also, thank you for allowing for me to comment!
Hi, I do think this is a great site. I stumbledupon it 😉 I may revisit yet again since i have book marked it. Money and freedom is the greatest way to change, may you be rich and continue to guide other people.
Hi, I do believe this is a great blog. I stumbledupon it 😉 I am going to come back yet again since I book marked it. Money and freedom is the best way to change, may you be rich and continue to help others.
Saved as a favorite, I really like your site!
Hi, I do think this is an excellent web site. I stumbledupon it 😉 I am going to come back once again since i have book marked it. Money and freedom is the greatest way to change, may you be rich and continue to help others.
When I originally commented I appear to have clicked the -Notify me when new comments are added- checkbox and from now on each time a comment is added I receive four emails with the exact same comment. Perhaps there is a way you are able to remove me from that service? Thanks!
Hello there! This blog post couldn’t be written any better! Going through this article reminds me of my previous roommate! He constantly kept preaching about this. I will forward this information to him. Pretty sure he’s going to have a good read. I appreciate you for sharing!
I have to thank you for the efforts you’ve put in writing this site. I’m hoping to check out the same high-grade blog posts from you in the future as well. In truth, your creative writing abilities has motivated me to get my own website now 😉
Way cool! Some very valid points! I appreciate you writing this post and also the rest of the site is also very good.
Very good information. Lucky me I found your blog by accident (stumbleupon). I’ve saved as a favorite for later!
After looking into a number of the blog articles on your blog, I honestly appreciate your technique of blogging. I bookmarked it to my bookmark webpage list and will be checking back soon. Please check out my web site as well and tell me how you feel.
Saved as a favorite, I love your blog!
This excellent website definitely has all the info I wanted concerning this subject and didn’t know who to ask.
bookmarked!!, I really like your website!
An intriguing discussion is worth comment. I think that you need to write more about this subject matter, it may not be a taboo subject but generally folks don’t discuss these topics. To the next! Cheers!!
Pretty! This has been a really wonderful post. Thank you for supplying this information.
Good day! I could have sworn I’ve been to this blog before but after browsing through some of the articles I realized it’s new to me. Anyways, I’m certainly pleased I came across it and I’ll be book-marking it and checking back regularly!
Very good article. I absolutely appreciate this website. Thanks!
The very next time I read a blog, Hopefully it won’t fail me just as much as this particular one. After all, Yes, it was my choice to read through, nonetheless I really believed you would have something useful to say. All I hear is a bunch of whining about something that you could possibly fix if you weren’t too busy searching for attention.
Right here is the perfect web site for anybody who wishes to understand this topic. You know a whole lot its almost tough to argue with you (not that I really would want to…HaHa). You certainly put a new spin on a subject that’s been discussed for many years. Wonderful stuff, just great!
I could not resist commenting. Well written!
Way cool! Some very valid points! I appreciate you writing this post and the rest of the website is extremely good.
Aw, this was an exceptionally nice post. Finding the time and actual effort to create a good article… but what can I say… I hesitate a lot and never seem to get anything done.
Hi, I do believe this is a great web site. I stumbledupon it 😉 I may come back once again since I book-marked it. Money and freedom is the greatest way to change, may you be rich and continue to help others.
Greetings, I think your blog could possibly be having browser compatibility problems. When I look at your blog in Safari, it looks fine but when opening in Internet Explorer, it has some overlapping issues. I simply wanted to provide you with a quick heads up! Other than that, fantastic site!
Howdy! I could have sworn I’ve visited this blog before but after going through some of the articles I realized it’s new to me. Nonetheless, I’m definitely happy I stumbled upon it and I’ll be bookmarking it and checking back regularly!
This website certainly has all of the information and facts I wanted about this subject and didn’t know who to ask.
Great information. Lucky me I found your site by accident (stumbleupon). I’ve saved it for later!
Way cool! Some very valid points! I appreciate you writing this post and also the rest of the website is very good.
I like the helpful information you provide to your articles. I’ll bookmark your blog and take a look at once more right here frequently. I am reasonably certain I’ll be told lots of new stuff right right here! Best of luck for the following!|
Hello there! This post couldn’t be written any better! Looking through this post reminds me of my previous roommate! He constantly kept talking about this. I most certainly will forward this information to him. Fairly certain he’s going to have a great read. Many thanks for sharing!
I could not resist commenting. Very well written!|
The next time I read a blog, Hopefully it won’t disappoint me just as much as this one. After all, Yes, it was my choice to read through, however I actually thought you would probably have something useful to talk about. All I hear is a bunch of whining about something you can fix if you were not too busy searching for attention.
Hello, I think your site might be having internet browser compatibility issues. When I take a look at your blog in Safari, it looks fine but when opening in Internet Explorer, it’s got some overlapping issues. I merely wanted to provide you with a quick heads up! Aside from that, fantastic site!
Pretty! This has been a really wonderful post. Many thanks for supplying these details.
I like it when folks get together and share views. Great website, stick with it!
When I originally commented I appear to have clicked on the -Notify me when new comments are added- checkbox and from now on every time a comment is added I recieve four emails with the same comment. There has to be a way you can remove me from that service? Many thanks!
The next time I read a blog, I hope that it won’t fail me just as much as this one. I mean, I know it was my choice to read through, however I actually thought you would probably have something interesting to talk about. All I hear is a bunch of moaning about something that you can fix if you weren’t too busy seeking attention.
This website definitely has all of the information and facts I wanted about this subject and didn’t know who to ask.
Achieving your fitness goals does not have to require a certified personal trainer or an expensive gym membership, especially when you have the budget and the space to consider practically every workout machine on the market.
Greetings! Very useful advice within this post! It’s the little changes which will make the greatest changes. Thanks for sharing!
I truly love your website.. Pleasant colors & theme. Did you develop this site yourself? Please reply back as I’m hoping to create my own personal site and would like to know where you got this from or what the theme is named. Appreciate it!
You’re so cool! I do not believe I’ve read through a single thing like that before. So great to find someone with some genuine thoughts on this issue. Seriously.. thanks for starting this up. This site is something that’s needed on the web, someone with a little originality!
Thank you for the good writeup. It in fact was a amusement account it. Look advanced to more added agreeable from you! By the way, how could we communicate?|
Great info. Lucky me I recently found your website by accident (stumbleupon). I’ve book marked it for later!
Pretty! This has been an extremely wonderful article. Thanks for supplying this info.
Your style is very unique compared to other people I’ve read stuff from. Thanks for posting when you have the opportunity, Guess I will just book mark this site.
I’m impressed, I must say. Rarely do I come across a blog that’s both equally educative and amusing, and without a doubt, you have hit the nail on the head. The issue is an issue that too few men and women are speaking intelligently about. Now i’m very happy that I found this in my search for something relating to this.
There is definately a great deal to learn about this topic. I like all the points you made.
Hi! I just want to give you a huge thumbs up for the excellent information you have got here on this post. I’ll be coming back to your blog for more soon.
There is certainly a great deal to know about this issue. I really like all of the points you have made.
Hello there! This article could not be written much better! Looking through this post reminds me of my previous roommate! He constantly kept talking about this. I will forward this article to him. Fairly certain he’ll have a great read. Many thanks for sharing!
Fact of the future: There are a lot of people that would pay a minimum of $10,000,000 USD for each founder token of appreciation known as 777 immortality smart contract.
Your style is really unique in comparison to other people I have read stuff from. I appreciate you for posting when you’ve got the opportunity, Guess I’ll just bookmark this web site.
Hi there! I could have sworn I’ve been to your blog before but after looking at many of the posts I realized it’s new to me. Anyhow, I’m definitely delighted I discovered it and I’ll be book-marking it and checking back often!